How Do Endocannabinoids Impact Digestion?
It is well known that many individuals use cannabidiol (CBD) as a type of supplement for numerous reasons. One of the more well-known reasons is that some people say that CBD reduces vomiting and nausea that may accompany illnesses such as cancer as well as the drugs used for treating these diseases. Other people have reported that CBD products appear to help with their digestion. An interview with a farmer showed that he had given CBD oil supplements to his pigs to successfully help with their ulcers!
You may be wondering why there should even be a potential connection between them. The reason why some individual might experience some form of connection between experiencing changes to their gastrointestinal systems by following a CBD regimen is not completely understood. However, the starting point to finding an answer to this question, lies in understanding how gastrointestinal and digestion activities are influenced by the endocannabinoid system.
Some studies have detailed a connection between various components of the body and brain that are involved in gastrointestinal health and hunger with endocannabinoid processes. Given that CBD can activate certain cannabinoid receptors, it might be able to influence the processes. So what kinds of proceses may be impacted by CBD?
Chickens were researched by the researchers Emadi et al. They found that the CB1 receptors inside the brain influence food and eating behavior. When they administered cannabinoids to activate CB1 recpetors, the chickens increased their food intake. However, when the CB1 receptors were inhibited, it resulted in less food being consumed among the chickens, in addition to feeling of fullness or faster satiation. Emadi et al. reviewed earlier research on mammals. They found that CB1 receptors within the brain appeared to influence sensations of fullness and hunger in the same ways. See here for CB2 Receptor Info.
A review of human research was conducted by Capasso and Izzo. They found that in animals and humans, that CB1 receptors related not only to satiation and hunger signals within the brain, but also in the gut. While mammals are digesting food inside their guts, within the gut the endocannabinoid system was providing the brain with feedback that informed the brain that no more food was necessary since the stomach was full. In turn, those signals, appeared to result in feelings of fullness. However, after the gut was emptied, endocannabinoid cells inside the gut started to produce anandamide, which is a type of endocannabinoid that might trigger feelings of being hungry. CB1 receptors were activated by these signals, and this in turn signals the brain that the digestion of food had progressed over to the intestine. Similarly, the intestine used anandamide production as a kind of signal for informing that brain via the endocannabinoid system that is was ready to have more food.
Most likely there are a number of other connections that exist between our digestion and eating habits with the endocannabinoid system that have not been discovered yet. These studies definitely give us things to think about on how CBD may activate hunger signals or suppress nausea when an individual needs to eat, but is sick. If you exist occasional nausea or indigestion, CBD might be a beneficial supplement for you. An obvious starting point is the wide assortment of CBD edibles that are available, including sugar-free chocolate bars. However, if you happen to have an upset stomach, you might want to try other CBD products like vape oils instead.
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